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Peer-Reviewed Publication
J Mol Diagn2023;25(3):143-155.March 1, 2023Journal Article

Contrived Materials and a Data Set for the Evaluation of Liquid Biopsy Tests: A Blood Profiling Atlas in Cancer (BLOODPAC) Community Study.

Kyle M Hernandez1, Kelli S Bramlett2, Phaedra Agius3, Jonathan Baden4, Ru Cao2, Omoshile Clement5, Adam S Corner6, Jonathan Craft7, Dennis A Dean8, Jonathan R Dry3, Kristina Grigaityte3, Robert L Grossman9, James Hicks10, Nikki Higa10, Timothy R Holzer11, Jeffrey Jensen12, Donald J Johann13, Sigrid Katz14, Anand Kolatkar10, Jennifer L Keynton15, Jerry S H Lee16, Dianna Maar6, Jean-Francois Martini17, Christopher G Meyer18, Peter C Roberts17, Matt Ryder7, Lea Salvatore19, Jeoffrey J Schageman2, Stella Somiari20, Daniel Stetson21, Mark Stern4, Liya Xu10, Lauren C Leiman22
1Department of Medicine, University of Chicago, Chicago, Illinois; Center for Translational Data Science, University of Chicago, Chicago, Illinois.
2Thermo Fisher Scientific, Austin, Texas.
3Tempus, Chicago, Illinois.
4Bristol Myers Squibb, Newton, New Jersey.
5SeraCare Life Sciences Inc., Milford, Massachusetts.
6Digital Biology Group, Bio-Rad Laboratories Inc., Pleasanton, California.
7Sysmex Inostics, Baltimore, Maryland.
8Seven Bridges, Charlestown, Massachusetts.
9Department of Medicine, University of Chicago, Chicago, Illinois; Open Commons Consortium, Chicago, Illinois; Pfizer, San Diego, California.
10Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA.
11Eli Lilly and Company, Indianapolis, Indiana.
12Fluxion Biosciences, San Francisco, California.
13Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
14Illumina, San Diego, California.
15Horizon Discovery, Cambridge, United Kingdom.
16Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA; Lawrence J. Ellison Institute for Transformative Medicine, Los Angeles, California.
17Pfizer, San Diego, California.
18Center for Translational Data Science, University of Chicago, Chicago, Illinois.
19Open Commons Consortium, Chicago, Illinois.
20Windber Research Institute, Windber, Pennsylvania.
21AstraZeneca, Waltham, Massachusetts.
22BLOODPAC, Chicago, Illinois. Electronic address: lauren@bloodpac.org.
PubMed DOI

Abstract

The Blood Profiling Atlas in Cancer (BLOODPAC) Consortium is a collaborative effort involving stakeholders from the public, industry, academia, and regulatory agencies focused on developing shared best practices on liquid biopsy. This report describes the results from the JFDI (Just Freaking Do It) study, a BLOODPAC initiative to develop standards on the use of contrived materials mimicking cell-f…

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