Health AI Central
Peer-Reviewed Publication
Biotechnol Prog2023;39(3):e3329.January 1, 2023Journal Article

Depth filter material process interaction in the harvest of mammalian cells.

Maria Parau1, James Pullen2, Daniel G Bracewell1
1Department of Biochemical Engineering, University College London, London, UK.
2Research and Development, FUJIFILM Diosynth Biotechnologies (FDB), Billingham, UK.
PubMed PMC DOI PDF

Abstract

Upstream advances have led to increased mAb titers above 5 g/L in 14-day fed-batch cultures. This is accompanied by higher cell densities and process-related impurities such as DNA and Host Cell Protein (HCP), which have caused challenges for downstream operations. Depth filtration remains a popular choice for harvesting CHO cell culture, and there is interest in utilizing these to remove process-…

Create a free account to keep reading

Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.

Create Free AccountSign In

Want unlimited research access? See Pro plans

Data Accuracy Notice: Research intelligence on Health AI Central is aggregated from public sources (PubMed, ClinicalTrials.gov, FDA, NIH, CMS, and others) and refreshed nightly. Classifications and derived metrics are produced by automated methods described in our Methodology. We recommend verifying critical data points against the primary sources before making decisions.