A Multicompartmental Diffusion Model for Improved Assessment of Whole-Body Diffusion-weighted Imaging Data and Evaluation of Prostate Cancer Bone Metastases.

Christopher C Conlin¹, Christine H Feng¹, Leonardino A Digma¹, Ana E Rodríguez-Soto¹, Joshua M Kuperman¹, Rebecca Rakow-Penner¹, David S Karow¹, Nathan S White¹, Tyler M Seibert¹, Michael E Hahn¹, Anders M Dale¹

¹From the Departments of Radiology (C.C.C., A.E.R.S., J.M.K., R.R.P., D.S.K., T.M.S., M.E.H., A.M.D.), Radiation Medicine and Applied Sciences (C.H.F., L.A.D., T.M.S.), and Neurosciences (A.M.D.), UC San Diego School of Medicine, 9452 Medical Center Dr, 4W 503, La Jolla, CA 92037; Human Longevity, Inc, San Diego, Calif (D.S.K.); CorTechs Labs, Inc, San Diego, Calif (N.S.W.); Department of Bioengineering, UC San Diego Jacobs School of Engineering, La Jolla, Calif (T.M.S.); and Halıcıoğlu Data Science Institute, UC San Diego, La Jolla, Calif (A.M.D.).

PubMed PMC DOI PDF

Abstract

Purpose To develop a multicompartmental signal model for whole-body diffusion-weighted imaging (DWI) and apply it to study the diffusion properties of normal tissue and metastatic prostate cancer bone lesions in vivo. Materials and Methods This prospective study (ClinicalTrials.gov: NCT03440554) included 139 men with prostate cancer (mean age, 70 years ± 9 [SD]). Multicompartmental models with two…

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Mentioned Companies

CorTechs Labs, Inc
affiliation

NIH Funding

Grant #11224993
Advanced diffusion MRI for evaluating early response to radiation treatment in cervical cancer
UNIVERSITY OF CALIFORNIA, SAN DIEGO
$648,284 (FY2026)

Other Funding

NCI NIH HHS(R37 CA249659)
United States
NCI NIH HHS(R44 CA268468)
United States
NICHD NIH HHS(U54 HD104393)
United States
NCI NIH HHS(R01 CA255780)
United States
NIBIB NIH HHS(K08 EB026503)
United States

MeSH Terms

Male0Humans0Aged0Prospective Studies0Bayes Theorem0Diffusion Magnetic Resonance Imaging0Magnetic Resonance Imaging0Prostatic Neoplasms*Bone Neoplasms*

Keywords

Bone MetastasesDiffusion Signal ModelDiffusion-weighted ImagingProstate CancerRestriction Spectrum ImagingWhole-Body MRI

Article Info

PMID: 36705559
PMCID: PMC9896230
DOI: 10.1148/rycan.210115

How to Cite

Conlin CC et al. A Multicompartmental Diffusion Model for Improved Assessment of Whole-Body Diffusion-weighted Imaging Data and Evaluation of Prostate Cancer Bone Metastases. Radiol Imaging Cancer2023;5(1):e210115. doi:10.1148/rycan.210115

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