Peer-Reviewed Publication
Hum Brain Mapp2023;44(4):1496-1514.March 1, 2023Journal Article
Linear multi-scale modeling of diffusion MRI data: A framework for characterization of oriented structures across length scales.
Barbara D Wichtmann1,2, Qiuyun Fan1,3, Laleh Eskandarian1, Thomas Witzel4, Ulrike I Attenberger2, Claus C Pieper2, Lothar Schad5, Bruce R Rosen1, Lawrence L Wald1,6, Susie Y Huang1,6, Aapo Nummenmaa1
1A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
2Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany.
3Department of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, China.
4Q Bio Inc., San Carlos, California, USA.
5Computer Assisted Clinical Medicine, Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
6Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Abstract
Diffusion-weighted magnetic resonance imaging (DW-MRI) has evolved to provide increasingly sophisticated investigations of the human brain's structural connectome in vivo. Restriction spectrum imaging (RSI) is a method that reconstructs the orientation distribution of diffusion within tissues over a range of length scales. In its original formulation, RSI represented the signal as consisting of a…
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