Multiparametric Quantitative Imaging Biomarker as a Multivariate Descriptor of Health: A Roadmap.

David L Raunig¹, Gene A Pennello², Jana G Delfino³, Andrew J Buckler⁴, Timothy J Hall⁵, Alexander R Guimaraes⁶, Xiaofeng Wang⁷, Erich P Huang⁸, Huiman X Barnhart⁹, Nandita deSouza¹⁰, Nancy Obuchowski¹¹

¹Department of Statistical and Quantitative Sciences, Data Science Institute, Takeda Pharmaceuticals, Cambridge, Massachusetts. Electronic address: draunig@snet.net.

²Center for Devices and Radiological Health, US Food and Drug Administration Division of Imaging, Diagnostic and Software Reliability, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland.

³Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland.

⁴Elucid Bioimaging, Inc., Boston, Massachusetts.

⁵Department of Medical Physics, University of Wisconsin, Madison, Wisconsin.

⁶Department of Diagnostic Radiology, Oregon Health & Sciences University, Portland, Oregon.

⁷Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland, Ohio.

⁸Biometric Research Program, Division of Cancer Treatment and Diagnosis - National Cancer Institute, National Institutes of Health, Bethesda, MD.

⁹Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina.

¹⁰Division of Radiotherapy and Imaging, the Insitute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom.

¹¹Department of Quantitative Health Sciences, Lerner Research Institute Cleveland Clinic Foundation, Cleveland, Ohio.

PubMed PMC DOI PDF

Abstract

Multiparametric quantitative imaging biomarkers (QIBs) offer distinct advantages over single, univariate descriptors because they provide a more complete measure of complex, multidimensional biological systems. In disease, where structural and functional disturbances occur across a multitude of subsystems, multivariate QIBs are needed to measure the extent of system malfunction. This paper, the fi…

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