Antidepressant drug-drug-drug interactions associated with unintentional traumatic injury: Screening for signals in real-world data.

Cheng Chen^1,2, Sean Hennessy^1,2,3,4, Colleen M Brensinger^1,2, Warren B Bilker^1,5, Sascha Dublin^6,7, Sophie P Chung⁸, John R Horn⁹, Kacie F Bogar^1,2, Charles E Leonard^1,2,3

¹Center for Real-World Effectiveness and Safety of Therapeutics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

²Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

³Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

⁴Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

⁵Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

⁶Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.

⁷Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.

⁸Epocrates Medical Information, AthenaHealth, Inc., Watertown, Massachusetts, USA.

⁹Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, Washington, USA.

PubMed PMC DOI PDF

Abstract

Antidepressants are associated with traumatic injury and are widely used with other medications. It remains unknown how drug-drug-drug interactions (3DIs) between antidepressants and two other drugs may impact potential injury risks associated with antidepressants. We aimed to generate hypotheses regarding antidepressant 3DI signals associated with elevated injury rates. Using 2000-2020 Optum's de…

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