Peer-Reviewed Publication
J Neurotrauma2023;40(3-4):309-317.February 1, 2023Journal Article

Long-Term Changes in Brain Connectivity Reflected in Quantitative Electrophysiology of Symptomatic Former National Football League Players.

Bo Liang1, Michael L Alosco2,3, Ruben Armañanzas1,4,5, Brett M Martin2, Yorghos Tripodis2,6, Robert A Stern2,3,7, Leslie S Prichep1
1BrainScope Company, Chevy Chase, Maryland, USA.
2Boston University CTE Center, Boston University, Boston, Massachusetts, USA.
3Department of Neurology, Boston University, Boston, Massachusetts, USA.
4Institute for Data Science and Artificial Intelligence, Universidad de Navarra, Pamplona, Spain.
5Tecnun School of Engineering, Universidad de Navarra, Donostia-San Sebastian, Spain.
6Department of Biostatistics, Boston University, Boston, Massachusetts, USA.
7Departments of Neurosurgery and Anatomy & Neurobiology, Boston University, Boston, Massachusetts, USA.

Abstract

Exposure to repetitive head impacts (RHI) has been associated with long-term disturbances in cognition, mood, and neurobehavioral dysregulation, and reflected in neuroimaging. Distinct patterns of changes in quantitative features of the brain electrical activity (quantitative electroencephalogram [qEEG]) have been demonstrated to be sensitive to brain changes seen in neurodegenerative disorders an…

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