Ovatodiolide and antrocin synergistically inhibit the stemness and metastatic potential of hepatocellular carcinoma via impairing ribosome biogenesis and modulating ERK/Akt-mTOR signaling axis.

Ming-Yao Chen¹, Chia-Hung Hsu², Syahru Agung Setiawan³, David T W Tzeng⁴, Hon-Ping Ma², Jiann Ruey Ong², Yi Cheng Chu⁵, Ming-Shou Hsieh⁶, Alexander T H Wu⁶, Yew-Min Tzeng⁷, Chi-Tai Yeh⁸

¹Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan.

²Department of Emergency Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan; Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei City 110, Taiwan; Department of Emergency Medicine, School of Medicine, Taipei Medical University, Taipei City 110, Taiwan.

³International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan; Department of Medical Research & Education, Taipei Medical University - Shuang-Ho Hospital, New Taipei City 235, Taiwan.

⁴School of Life Sciences, The Chinese University of Hong Kong, Hong Kong SAR, 999077, China; Lifebit, Mindspace Shoreditch, London, England, EC2A 2AP, UK.

⁵Department of Medicine, St. George's University School of Medicine, St. George, Grenada.

⁶Department of Medical Research & Education, Taipei Medical University - Shuang-Ho Hospital, New Taipei City 235, Taiwan.

⁷Department of Applied Science, National Taitung University, Taitung 95092, Taiwan. Electronic address: ymtzeng@nttu.edu.tw.

⁸Department of Medical Research & Education, Taipei Medical University - Shuang-Ho Hospital, New Taipei City 235, Taiwan; Continuing Education Program of Food Biotechnology Applications, College of Science and Engineering, National Taitung University, Taitung 95092, Taiwan. Electronic address: ctyeh@s.tmu.edu.tw.

PubMed DOI

Abstract

Activation of mitogen-activated protein kinase (MAPK) and PI3K signaling confers resistance against sorafenib, a mainstay treatment for advanced hepatocellular carcinoma (HCC). Antrocin and ovatodiolide constitute as the most potent secondary metabolites isolated from Antrodia camphorata and Anisomeles indica, respectively. Both natural compounds have recently gained a lot of attention due to thei…

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