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Peer-Reviewed Publication
NMR Biomed2023;36(2):e4831.February 1, 2023Journal Article

High-fidelity, high-spatial-resolution diffusion magnetic resonance imaging of ex vivo whole human brain at ultra-high gradient strength with structured low-rank echo-planar imaging ghost correction.

Gabriel Ramos-Llordén1,2, Rodrigo A Lobos3, Tae Hyung Kim1,2,4, Qiyuan Tian1,2, Thomas Witzel5, Hong-Hsi Lee1,2, Alina Scholz6, Boris Keil6,7, Anastasia Yendiki1,2, Berkin Bilgiç1,2,8, Justin P Haldar3, Susie Y Huang1,2,8
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
2Department of Radiology, Harvard Medical School, Boston, Massachusetts, USA.
3Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, California, USA.
4Computer Engineering, Hongik University, Seoul, Republic of Korea.
5Q Bio Inc, San Carlos, California, USA.
6Institute of Medical Physics and Radiation Protection, Mittelhessen University of Applied Sciences, Giessen, Germany.
7Department of Diagnostic and Interventional Radiology, University Hospital Marburg, Philipps University of Marburg, Marburg, Germany.
8Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
PubMed PMC DOI PDF

Abstract

Diffusion magnetic resonance imaging (dMRI) of whole ex vivo human brain specimens enables three-dimensional (3D) mapping of structural connectivity at the mesoscopic scale, providing detailed evaluation of fiber architecture and tissue microstructure at a spatial resolution that is difficult to access in vivo. To account for the short T2 and low diffusivity of fixed tissue, ex vivo dMRI is often…

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