Peer-Reviewed Publication
J Imaging2022;8(8)July 31, 2022Journal Article
HEROHE Challenge: Predicting HER2 Status in Breast Cancer from Hematoxylin-Eosin Whole-Slide Imaging.
Eduardo Conde-Sousa1,2, João Vale1,3, Ming Feng4, Kele Xu5, Yin Wang4, Vincenzo Della Mea6, David La Barbera6, Ehsan Montahaei7, Mahdieh Baghshah7, Andreas Turzynski8, Jacob Gildenblat9, Eldad Klaiman10, Yiyu Hong11, Guilherme Aresta12,13, Teresa Araújo12,13, Paulo Aguiar1,2, Catarina Eloy1,3,14, Antonio Polónia1,3
1I3S-Instituto de Investigação e Inovação em Saúde, Universidade Do Porto, 4200-135 Porto, Portugal.
2INEB-Instituto de Engenharia Biomédica, Universidade Do Porto, 4200-135 Porto, Portugal.
3Department of Pathology, Ipatimup Diagnostics, Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.
4College of Electronic and Information Engineering, Tongji University, Shanghai 201804, China.
5School of Computer, National University of Defense Technology, Changsha 410073, China.
6Department of Mathematics, Computer Science and Physics, University of Udine, 33100 Udine, Italy.
7Computer Engineering Department, Sharif University of Technology, Tehran 1458889694, Iran.
8Private Group Practice for Pathology, 23552 Lübeck, Germany.
9DeePathology, Hatidhar 5, Raanana 4365104, Israel.
10Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany.
11Department of R&D Center, Arontier Co., Ltd., Seoul 06735, Korea.
12INESC TEC-Institute for Systems and Computer Engineering, Technology and Science, 4200-465 Porto, Portugal.
13FEUP-Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal.
14FMUP-Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
Abstract
Breast cancer is the most common malignancy in women worldwide, and is responsible for more than half a million deaths each year. The appropriate therapy depends on the evaluation of the expression of various biomarkers, such as the human epidermal growth factor receptor 2 (HER2) transmembrane protein, through specialized techniques, such as immunohistochemistry or in situ hybridization. In this w…
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