Inadequate Oxygen Delivery Dose and Major Adverse Events in Critically Ill Children With Sepsis.

Katie L Roy¹, Anna Fisk², Peter Forbes³, Conor C Holland⁴, Sara R Schenkel⁵, Sally Vitali⁶, Michele DeGrazia⁷

¹Katie L. Roy is a nurse practitioner in the medical-surgical intensive care unit (ICU), Cardiovascular and Critical Care Services, Boston Children's Hospital, and a DNP graduate, Northeastern University, Boston, Massachusetts.

²Anna Fisk is a clinical coordinator in the cardiovascular ICU, Cardiovascular and Critical Care Services, Boston Children's Hospital.

³Peter Forbes is a senior biostatistician, Institutional Centers for Clinical and Translational Research, Boston Children's Hospital.

⁴Conor C. Holland is a research engineer, Etiometry Inc, Boston, Massachusetts.

⁵Sara R. Schenkel is a clinical research program manager, Massachusetts General Hospital, Boston.

⁶Sally Vitali is a senior associate in critical care medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, and an assistant professor of anesthesia, Harvard Medical School, Boston, Massachusetts.

⁷Michele DeGrazia is director of nursing research, neonatal ICU, Cardiovascular and Critical Care Services, Boston Children's Hospital, and an assistant professor of pediatrics, Harvard Medical School.

PubMed DOI

Abstract

BACKGROUND: The inadequate oxygen delivery (IDo2) index is used to estimate the probability that a patient is experiencing inadequate systemic delivery of oxygen. Its utility in the care of critically ill children with sepsis is unknown. OBJECTIVE: To evaluate the relationship between IDo2 dose and major adverse events, illness severity metrics, and outcomes among critically ill children with sep…

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