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Peer-Reviewed Publication
PLoS One2022;17(3):e0265756.January 1, 2022Journal Article

An atlas of robust microbiome associations with phenotypic traits based on large-scale cohorts from two continents.

Daphna Rothschild1,2, Sigal Leviatan1,2, Ariel Hanemann3, Yossi Cohen3, Omer Weissbrod4, Eran Segal1,2
1Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
2Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
3DayTwo LTD, Tel Aviv, Israel.
4Epidemiology Department, Harvard T.H. Chan School of Public Health, Boston, MA, United States of America.
PubMed PMC DOI PDF

Abstract

Numerous human conditions are associated with the microbiome, yet studies are inconsistent as to the magnitude of the associations and the bacteria involved, likely reflecting insufficiently employed sample sizes. Here, we collected diverse phenotypes and gut microbiota from 34,057 individuals from Israel and the U.S.. Analyzing these data using a much-expanded microbial genomes set, we derive an…

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