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Peer-Reviewed Publication
Nat Microbiol2022;7(2):277-288.February 1, 2022Journal Article

Predominance of antibody-resistant SARS-CoV-2 variants in vaccine breakthrough cases from the San Francisco Bay Area, California.

Venice Servellita1,2, Mary Kate Morris3, Alicia Sotomayor-Gonzalez1,2, Amelia S Gliwa1,2, Erika Torres4, Noah Brazer1,2, Alicia Zhou4, Katherine T Hernandez5, Madeline Sankaran5, Baolin Wang1,2, Daniel Wong1,2, Candace Wang1,2, Yueyuan Zhang1,2, Kevin R Reyes1,2, Dustin Glasner1,2, Xianding Deng1,2, Jessica Streithorst1,2, Steve Miller1,2, Edwin Frias6, Mary Rodgers6, Gavin Cloherty6, John Hackett6, Carl Hanson3, Debra Wadford3, Susan Philip5, Scott Topper4, Darpun Sachdev5, Charles Y Chiu7,8,9,10
1Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
2UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA.
3Viral and Rickettsial Disease Laboratory, California Department of Public Health, Richmond, CA, USA.
4Color Genomics, Inc., Burlingame, CA, USA.
5San Francisco Department of Public Health, San Francisco, CA, USA.
6Abbott Laboratories, Abbott Park, IL, USA.
7Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA. charles.chiu@ucsf.edu.
8UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA. charles.chiu@ucsf.edu.
9Department of Medicine, University of California San Francisco, San Francisco, CA, USA. charles.chiu@ucsf.edu.
10Innovative Genomics Institute, University of California Berkeley, Berkeley, CA, USA. charles.chiu@ucsf.edu.
PubMed DOI

Abstract

Associations between vaccine breakthrough cases and infection by different SARS coronavirus 2 (SARS-CoV-2) variants have remained largely unexplored. Here we analysed SARS-CoV-2 whole-genome sequences and viral loads from 1,373 persons with COVID-19 from the San Francisco Bay Area from 1 February to 30 June 2021, of which 125 (9.1%) were vaccine breakthrough infections. Vaccine breakthrough infect…

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