X-ray dark-field chest imaging for detection and quantification of emphysema in patients with chronic obstructive pulmonary disease: a diagnostic accuracy study.

Konstantin Willer¹, Alexander A Fingerle², Wolfgang Noichl³, Fabio De Marco³, Manuela Frank³, Theresa Urban³, Rafael Schick³, Alex Gustschin³, Bernhard Gleich³, Julia Herzen³, Thomas Koehler⁴, Andre Yaroshenko⁵, Thomas Pralow⁵, Gregor S Zimmermann⁶, Bernhard Renger², Andreas P Sauter², Daniela Pfeiffer⁷, Marcus R Makowski², Ernst J Rummeny², Philippe A Grenier⁸, Franz Pfeiffer⁹

¹Department of Physics, Technical University of Munich, Garching, Germany; Munich School of BioEngineering, Technical University of Munich, Garching, Germany. Electronic address: konstantin.willer@ph.tum.de.

²Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

³Department of Physics, Technical University of Munich, Garching, Germany; Munich School of BioEngineering, Technical University of Munich, Garching, Germany.

⁴Institute for Advanced Study, Technical University of Munich, Garching, Germany; Philips Research Hamburg, Hamburg, Germany.

⁵Philips Medical Systems DMC Hamburg, Hamburg, Germany.

⁶Department of Cardiology, Angiology, and Pneumology, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

⁷Institute for Advanced Study, Technical University of Munich, Garching, Germany; Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

⁸Department of Clinical Research and Innovation, Hôpital Foch, Suresnes, Paris, France.

⁹Department of Physics, Technical University of Munich, Garching, Germany; Munich School of BioEngineering, Technical University of Munich, Garching, Germany; Institute for Advanced Study, Technical University of Munich, Garching, Germany; Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Although advanced medical imaging technologies give detailed diagnostic information, a low-dose, fast, and inexpensive option for early detection of respiratory diseases and follow-ups is still lacking. The novel method of x-ray dark-field chest imaging might fill this gap but has not yet been studied in living humans. Enabling the assessment of microstructural changes in lung parenchy…

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