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J Nutr2021;151(10):2894-2907.October 1, 2021Journal Article

Plasma Metabolomic Signatures of Healthy Dietary Patterns in the Chronic Renal Insufficiency Cohort (CRIC) Study.

Hyunju Kim1,2, Cheryl Am Anderson3, Emily A Hu4, Zihe Zheng5, Lawrence J Appel1,2, Jiang He6,7, Harold I Feldman5, Amanda H Anderson6, Ana C Ricardo8, Zeenat Bhat9, Tanika N Kelly6,7, Jing Chen6,7, Ramachandran S Vasan10, Paul L Kimmel11, Morgan E Grams1,2, Josef Coresh1,2, Clary B Clish12, Eugene P Rhee13, Casey M Rebholz1,2
1Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD, USA.
2Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
3Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, CA, USA.
4Foodsmart, San Francisco, CA, USA.
5Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.
6Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
7Department of Medicine, Tulane University, New Orleans, LA, USA.
8Department of Medicine, University of Illinois, Chicago, IL, USA.
9Department of Medicine, Wayne State University, Detroit, MI, USA.
10Department of Medicine, Boston University, Boston, MA, USA.
11Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
12The Broad Institute of Harvard and Massachusetts Institute of Technology , Boston, MA, USA.
13Nephrology Division and Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
PubMed PMC DOI PDF

Abstract

BACKGROUND: In individuals with chronic kidney disease (CKD), healthy dietary patterns are inversely associated with CKD progression. Metabolomics, an approach that measures many small molecules in biofluids, can identify biomarkers of healthy dietary patterns. OBJECTIVES: We aimed to identify known metabolites associated with greater adherence to 4 healthy dietary patterns in CKD patients. METH…

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