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Peer-Reviewed Publication
Cogn Affect Behav Neurosci2021;21(4):679-697.August 1, 2021Journal Article

The Imbalanced Plasticity Hypothesis of Schizophrenia-Related Psychosis: A Predictive Perspective.

Yossi Guterman1, Yochai Ataria2, Steven M Silverstein3
1Tel-Hai College, D.N Galil Elion, Haklarnit 3, 7557103, Rishon-LeZion, Israel. yossigut@gmail.com.
2Tel-Hai College, D.N Galil Elion, Haklarnit 3, 7557103, Rishon-LeZion, Israel.
3University of Rochester, 300 Crittenden Blvd., Rochester, NY, 14642, USA.
PubMed DOI

Abstract

A considerable number of studies have attempted to account for the psychotic aspects of schizophrenia in terms of the influential predictive coding (PC) hypothesis. We argue that the prediction-oriented perspective on schizophrenia-related psychosis may benefit from a mechanistic model that: 1) gives due weight to the extent to which alterations in short- and long-term synaptic plasticity determin…

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