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Alcohol Clin Exp Res2019;43(12):2627-2636.December 1, 2019Journal Article

Effects of Oxytocin Administration on Cue-Induced Craving in Co-occurring Alcohol Use Disorder and PTSD: A Within-Participant Randomized Clinical Trial.

Christopher S Stauffer1, Nathan K Meinzer2, Tyler Morrison3, Jin-Hui Wen4, Lily Radanovich5, David Leung5, Andrea Niles6, Aoife O'Donovan5, Steven L Batki1, Joshua D Woolley1
1From the, San Francisco Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, California.
2Huron Consulting Group, Inc, Portland, Oregon.
3University of California, San Francisco, San Francisco, California.
4University of British Columbia, Vancouver, British Columbia.
5San Francisco Veterans Affairs Medical Center, San Francisco, California.
6Youper, Inc., San Francisco, California.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Individuals with alcohol use disorder (AUD) are much more likely to meet criteria for posttraumatic stress disorder (PTSD) than the general population. Compared to AUD alone, those with comorbid AUD-PTSD experience worse outcomes. Prior literature suggests that oxytocin, a hypothalamic neuropeptide, may be effective in the treatment of both AUD and PTSD when administered intranasally,…

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