Inadequate oxygen delivery index dose is associated with cardiac arrest risk in neonates following cardiopulmonary bypass surgery.

Craig Futterman¹, Joshua W Salvin², Michael McManus³, Adam W Lowry⁴, Dimitar Baronov⁵, Melvin C Almodovar⁶, Jose A Pineda⁷, Vinay M Nadkarni⁸, Peter C Laussen⁹, Avihu Z Gazit¹⁰

¹Division of Cardiac Critical Care Medicine, George Washington University, Children's National Medical Center, 111 Michigan Avenue, NW Washington DC, 200010 United States. Electronic address: cfutterm@cnmc.org.

²Department of Cardiology, Division of Cardiovascular Critical Cares Medicine, Harvard Medical School, Boston Children's Hospital, 300 Longwood Avenue, Boston MA 02115 United States. Electronic address: joshua.salvin@cardio.chboston.org.

³Etiometry, Inc 280 Summer St fl 4, Boston, MA 02210, United States. Electronic address: mmcmanus@etiometry.com.

⁴Department of Cardiovascular Services, Division of Cardiac Critical Care, University of Central Florida, Nemours Cardiac Center, Nemours Children's Hospital, 13535 Nemours Parkway, Orlando, FL 32827, United States. Electronic address: adam.lowry@nemours.org.

⁵Etiometry, Inc 280 Summer St fl 4, Boston, MA 02210, United States. Electronic address: baronov@etiometry.com.

⁶Department of Pediatrics, Divisions of Cardiology and Critical Care Medicine, University of Miami Miller School of Medicine, Holtz Children's Hospital/Jackson Health System, 1611 NW 12th Avenue, North Wing, Suite 109 Miami, FL 33136 United States. Electronic address: melalmodovar@med.miami.edu.

⁷Department of Pediatrics and Neurology, Washington University School of Medicine, Saint Louis Children's Hospital, 1 Children's Place, St. Louis, MO 63110, United States. Electronic address: pineda_j@wustl.edu.

⁸Department of Anesthesiology, Critical Care, and Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, 3401 Civic Center Boulevard, Philadelphia, PA, 19104 United States. Electronic address: Nadkarni@email.chop.edu.

⁹Department of Critical Care Medicine, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, M5G 1X8, Canada. Electronic address: Peter.laussen@sickkids.ca.

¹⁰Department of Pediatrics, Divisions of Critical Care Medicine and Cardiology, Washington University School of Medicine, Saint Louis Children's Hospital, 1 Children's Place St. Louis MO 63110, United States. Electronic address: Gazit_a@wustl.edu.

PubMed PMC DOI PDF

Abstract

AIM: To evaluate the Inadequate oxygen delivery (IDO2) index dose as a predictor of cardiac arrest (CA) in neonates following congenital heart surgery. METHODS: Retrospective cohort study in 3 US pediatric cardiac intensive units (1/2011- 8/2016). Calculated IDO2 index values were blinded to bedside clinicians and generated from data collected up to 30 days postoperatively, or until death or ECMO…

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Mentioned Companies

Etiometry
affiliation

NIH Funding

Grant #8510725
Risk Assessment Using Noninvasive Measurements in Postoperative Pediatric Patient
ETIOMETRY, LLC
$249,547 (FY2013)
Grant #9931264
Risk-based Patient Monitoring for Pediatric Cardiac Patients
ETIOMETRY, LLC
$999,708 (FY2020)

Other Funding

NHLBI NIH HHS(R43 HL117340)
United States
NHLBI NIH HHS(R44 HL117340)
United States

MeSH Terms

Cardiac Surgical Procedures*Cardiopulmonary Bypass*Female0Heart Arrest*Heart Defects, Congenital0Humans0Infant, Newborn0Male0Monitoring, Physiologic*Outcome and Process Assessment, Health Care0Oxygen*Postoperative Complications*Prognosis0Risk Assessment0Time Factors0

Keywords

CICUCardiac arrestCritical congenital heart diseaseIDO2 doseIDO2 indexPediatric cardiac critical carePrediction

Article Info

PMID: 31325555
PMCID: PMC6733252
DOI: 10.1016/j.resuscitation.2019.07.013
Received: December 31, 2018
Accepted: July 9, 2019

How to Cite

Futterman C et al. Inadequate oxygen delivery index dose is associated with cardiac arrest risk in neonates following cardiopulmonary bypass surgery. Resuscitation2019;14274-80. doi:10.1016/j.resuscitation.2019.07.013

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