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Peer-Reviewed Publication
J Pathol Inform2018;945.January 1, 2018Journal Article

Computer-Aided Laser Dissection: A Microdissection Workflow Leveraging Image Analysis Tools.

Jason D Hipp1,2, Donald J Johann3, Yun Chen1,4, Anant Madabhushi5, James Monaco6, Jerome Cheng7, Jaime Rodriguez-Canales1,8, Martin C Stumpe2, Greg Riedlinger1,9, Avi Z Rosenberg1,10, Jeffrey C Hanson1, Lakshmi P Kunju7, Michael R Emmert-Buck1,11, Ulysses J Balis7, Michael A Tangrea1,12
1Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA.
2Google Inc., Mountain View, CA, USA.
3Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
4Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
5Department of Biomedical Engineering, Center for Computational Imaging and Personalized Diagnostics, Case Western Reserve University, Cleveland, OH, USA.
6Inspirata Inc., Tampa, FL, USA.
7Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
8Medimmune, LLC, Gaithersburg, MD, USA.
9Division of Translational Pathology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
10Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
11Avoneaux Medical Institute, LLC, Baltimore, MD, USA.
12Alvin and Lois Lapidus Cancer Institute, Sinai Hospital of Baltimore, LifeBridge Health, Baltimore, MD, USA.
PubMed PMC DOI PDF

Abstract

INTRODUCTION: The development and application of new molecular diagnostic assays based on next-generation sequencing and proteomics require improved methodologies for procurement of target cells from histological sections. Laser microdissection can successfully isolate distinct cells from tissue specimens based on visual selection for many research and clinical applications. However, this can be a…

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