Peer-Reviewed Publication
Magn Reson Imaging2017;38152-162.May 1, 2017Journal Article
Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques.
Eugene Milshteyn1, Cornelius von Morze2, Galen D Reed3, Hong Shang1, Peter J Shin2, Zihan Zhu1, Hsin-Yu Chen1, Robert Bok2, Andrei Goga4, John Kurhanewicz1, Peder E Z Larson1, Daniel B Vigneron5
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA; UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, CA, USA.
2Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
3HeartVista Inc., Los Altos, CA, USA.
4Department of Cell and Tissue Biology, University of California, San Francisco, CA, USA.
5Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA; UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, CA, USA. Electronic address: dan.vigneron@ucsf.edu.
Abstract
The goal of this project was to develop and apply techniques for T2 mapping and 3D high resolution (1.5mm isotropic; 0.003cm3) 13C imaging of hyperpolarized (HP) probes [1-13C]lactate, [1-13C]pyruvate, [2-13C]pyruvate, and [13C,15N2]urea in vivo. A specialized 2D bSSFP sequence was implemented on a clinical 3T scanner and used to obtain the first high resolution T2 maps of these different hyperpol…
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