Senescence-associated Long Non-coding RNA (SALNR) Delays Oncogene-induced Senescence through NF90 Regulation.

Cheng-Lin Wu¹, Yu Wang², Bo Jin¹, Hao Chen¹, Bu-Shan Xie³, Ze-Bin Mao⁴

¹From the Department of Biochemistry and Molecular Biology and Beijing Key Laboratory for "Posttranslational Modification and Cellular Function," Health Science Center, Peking University, 38 Xueyuan Road, Beijing 100191, China.

²the Departments of Urology and Microbiology, New York University Medical Center, New York, New York 10016, and.

³the Department of Gastroenterology, First Affiliated Hospital of Nanchang University, 17 Yongwai Zheng Street, Nanchang 330000, China.

⁴From the Department of Biochemistry and Molecular Biology and Beijing Key Laboratory for "Posttranslational Modification and Cellular Function," Health Science Center, Peking University, 38 Xueyuan Road, Beijing 100191, China, zbmao@bjmu.edu.cn.

PubMed PMC DOI PDF

Abstract

Long non-coding RNAs (lncRNAs) have recently emerged as key players in many physiologic and pathologic processes. Although many lncRNAs have been identified, few lncRNAs have been characterized functionally in aging. In this study, we used human fibroblast cells to investigate genome-wide lncRNA expression during cellular senescence. We identified 968 down-regulated lncRNAs and 899 up-regulated ln…

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