Between-Scanner and Between-Visit Variation in Normal White Matter Apparent Diffusion Coefficient Values in the Setting of a Multi-Center Clinical Trial.

J Huo¹, J Alger², H Kim², M Brown², K Okada³, W Pope², J Goldin²

¹TeraRecon Inc., 4000 E 3rd Ave., Suite 200, 94404, Foster City, CA, USA. jinghuo@gmail.com.

²Department of Radiological Science, University of California in Los Angeles, 924 Westwood Blvd, Suite 650, 90024, Los Angeles, CA, USA.

³Department of Computer Science, San Francisco State University, San Francisco, USA.

PubMed DOI

Abstract

PURPOSE: To study the between-scanner variation and the between-visit reproducibility of brain apparent diffusion coefficient (ADC) measurements in the setting of a multi-center chemotherapy clinical trial for glioblastoma multiforme. METHODS AND MATERIALS: ADC maps of 52 patients at six sites were calculated in-house from diffusion-weighted images obtained by seven individual scanner models of t…

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