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Peer-Reviewed Publication
Cell Microbiol2007;9(5):1336-42.May 1, 2007Journal Article

Inhibitors of bacterial virulence identified in a surrogate host model.

Mohammed Benghezal1, Eric Adam, Aurore Lucas, Christine Burn, Michael G Orchard, Christine Deuschel, Emilio Valentino, Stéphanie Braillard, Jean-Pierre Paccaud, Pierre Cosson
1Athelas SA, Chemin des Aulx 18, CH-1228 Plan-les-Ouates, Switzerland. mb.benghezal@bluemail.ch
PubMed DOI

Abstract

Antibiotic resistance continues to reduce the number of available antibiotics, increasing the need for novel antibacterial drugs. Since the seminal work of Sir Alexander Fleming, antibiotic identification has been based exclusively on the inhibition of bacterial growth in vitro. Recently, inhibitors of bacterial virulence which interfere with bacterial pathogenesis mechanisms have been proposed as…

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