Specific host genes required for the killing of Klebsiella bacteria by phagocytes.

Mohammed Benghezal¹, Marie-Odile Fauvarque, Régis Tournebize, Romain Froquet, Anna Marchetti, Evelyne Bergeret, Bernard Lardy, Gérard Klein, Philippe Sansonetti, Steve J Charette, Pierre Cosson

¹Athelas SA, Chemin des Aulx 18, 1228 Plan-les-Ouates, Geneva, Switzerland.

PubMed DOI

Abstract

The amoeba Dictyostelium discoideum shares many traits with mammalian macrophages, in particular the ability to phagocytose and kill bacteria. In response, pathogenic bacteria use conserved mechanisms to fight amoebae and mammalian phagocytes. Here we developed an assay using Dictyostelium to monitor phagocyte-bacteria interactions. Genetic analysis revealed that the virulence of Klebsiella pneumo…

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